We read with interest the article by Meek et al. (1). The authors have measured maternal serum C-peptide concentrations at 12, 24, and 34 weeks of gestation in 127 pregnant women with type 1 diabetes and cord blood C-peptide concentrations. In 74 (58%) pregnant women, C-peptide was not detected; in 22 (17%), it was confirmed at the beginning of pregnancy; and in 31 (24%), it was detected in the 34th week of pregnancy (1). Neonates born to mothers in whom C-peptide was detected at 34 weeks of gestation had elevated cord blood C-peptide and more frequent neonatal complications than others (1). Based on the results, the authors suggest a transfer of C-peptide from fetal to maternal serum without the regeneration of pregnancy-related β-cells.
…. more: Diabetes Journals (ADA) (Quelle/Source)