Diabetes News-Stream

Aggregierte Informationen zum Diabetes, Insulin und Diabetes mellitus für Diabetiker.

  • Startseite
  • News
  • Über
  • Datenschutz
    • Datenauszug
    • Löschanfrage
  • Impressum
    • Kontakt
Aktuelle Seite: Startseite / Diabetes / Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

2. Januar 2022 19:34

Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

We previously demonstrated that male, but not female, Swiss Webster mice are susceptible to diabetes, with incidence increased by early overnutrition and high-fat diet (HFD). In this study, we investigated how HFD in Swiss Webster males and females during preweaning, peripubertal, and postpubertal periods alters glucose homeostasis and diabetes susceptibility. In males, HFD throughout life resulted in the highest diabetes incidence. Notably, switching to chow postpuberty was protective against diabetes relative to switching to chow at weaning, despite the longer period of HFD exposure. Similarly, HFD throughout life in males resulted in less liver steatosis relative to mice with shorter duration of postpubertal HFD. Thus, HFD timing relative to weaning and puberty, not simply exposure length, contributes to metabolic outcomes. Females were protected from hyperglycemia regardless of length or timing of HFD. However, postpubertal HFD resulted in a high degree of hepatic steatosis and adipose fibrosis, but glucose regulation and insulin sensitivity remained unchanged. Interestingly, peri-insulitis was observed in the majority of females but was not correlated with impaired glucose regulation. Our findings reveal critical periods of HFD-induced glucose dysregulation with striking sex differences in Swiss Webster mice, highlighting the importance of careful consideration of HFD timing relative to critical developmental periods.

…. more: Diabetes Journals (ADA) (Quelle/Source)

Beitrag teilen
  • twittern 
  • teilen  
  • mitteilen 
  • teilen 

Ähnliche Beiträge

  • Facebook
  • LinkedIn
  • RSS
  • Twitter
  • XING

Copyright © 2023 Afra Schmidt · Website by Firstmover Pro ·Idee Thomas Schmidt

WP DSGVO Tools (GDPR) for Wordpress and WooCommerce Sofern Sie Ihre Datenschutzeinstellungen ändern möchten z.B. Erteilung von Einwilligungen, Widerruf bereits erteilter Einwilligungen klicken Sie auf nachfolgenden Button. Einstellungen